Fr. James Alberione, founder of the Pauline Family, is the man behind the Pauline Spirituality. The spirituality is primarily biblical. It is based on the Person of Christ who defined and revealed himself as the "Master" (John 13:3), "the Way, the Truth and the Life" (John 14:6). Jesus is not just one of the many masters; he is the Master.

Blessed James Alberione sees the Pauline spirituality as a tool that transforms and helps a person respond to his or her call in life as God willed it. In this Christocentric spirituality, an individual is invited to a relationship with Jesus with their entire being. From the anthropological-theological view of his time, Blessed Alberione viewed the human person as composed of mind, will and heart. In the Pauline Spirituality, each of these faculties corresponds to an aspect of Jesus' Way-Truth-Life triad.  The mind is brought to the knowledge of and sanctification in Christ the Truth, one's will to the imitation and conformation with Christ the Way and one's heart is modelled on and nourished in Christ the Life. Thus the entire person enters on a journey of continued conversion and sanctification to the point where they can say with St. Paul, "it is no longer I who live, but it is Christ who lives in me" (Gal 2:20).